Inactivation of Rb and E2f8 Synergizes To Trigger Stressed DNA Replication during Erythroid Terminal Differentiation

Rb is critical for promoting cell cycle exit in cells undergoing terminal differentiation. Here we show that during erythroid terminal differentiation, Rb plays a previously unappreciated and unorthodox role in promoting DNA replication and cell cycle progression. Specifically, inactivation of Rb in...

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Detalhes bibliográficos
Main Authors: Ghazaryan, Seda, Sy, Chandler, Hu, Tinghui, An, Xiuli, Mohandas, Narla, Fu, Haiqing, Aladjem, Mirit I., Chang, Victor T., Opavsky, Rene, Wu, Lizhao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135565/
https://ncbi.nlm.nih.gov/pubmed/24865965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01651-13
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