Inactivation of Rb and E2f8 Synergizes To Trigger Stressed DNA Replication during Erythroid Terminal Differentiation

Rb is critical for promoting cell cycle exit in cells undergoing terminal differentiation. Here we show that during erythroid terminal differentiation, Rb plays a previously unappreciated and unorthodox role in promoting DNA replication and cell cycle progression. Specifically, inactivation of Rb in...

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Autori principali: Ghazaryan, Seda, Sy, Chandler, Hu, Tinghui, An, Xiuli, Mohandas, Narla, Fu, Haiqing, Aladjem, Mirit I., Chang, Victor T., Opavsky, Rene, Wu, Lizhao
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135565/
https://ncbi.nlm.nih.gov/pubmed/24865965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01651-13
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