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The Structure of Chondroitin B Lyase Complexed with Glycosaminoglycan Oligosaccharides Unravels a Calcium-dependent Catalytic Machinery

Chondroitinase B from Pedobacter heparinus is the only known enzyme strictly specific for dermatan sulfate and is a widely used enzymatic tool for the structural characterization of glycosaminoglycans. This β-helical polysaccharide lyase belongs to family PL-6 and cleaves the β(1,4) linkage of derma...

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Detalhes bibliográficos
Main Authors: Michel, Gurvan, Pojasek, Kevin, Li, Yunge, Sulea, Traian, Linhardt, Robert J., Raman, Rahul, Prabhakar, Vikas, Sasisekharan, Ram, Cygler, Miroslaw
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135467/
https://ncbi.nlm.nih.gov/pubmed/15155751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M403421200
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