Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation.

The p53 tumor suppressor protein can bind tightly to specific sequence elements in the DNA and induce the transactivation of genes harboring such p53 binding sites. Various lines of evidence suggest that p53 binds to its target site as an oligomer. To test whether oligomerization is essential for th...

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Bibliografiske detaljer

Udgivet i:	EMBO J
Principais autores:	Shaulian, E, Zauberman, A, Milner, J, Davies, E A, Oren, M
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 1993
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413529/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8334995/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05940.x
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