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Variation in AKR1C3, which Encodes the Neuroactive Steroid Synthetic Enzyme 3α-HSD Type 2 (17β-HSD Type 5), Moderates the Subjective Effects of Alcohol

RATIONALE: Animal models suggest that neuroactive steroids contribute to alcohol’s acute effects. We previously reported that a common non-synonymous polymorphism, AKR1C3*2 in the gene encoding the enzyme 3α-HSD2/17β-HSD5 and a synonymous SNP, rs248793, in SRD5A1, which encodes 5α-reductase, were as...

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Bibliografiset tiedot
Päätekijät: Milivojevic, Verica, Feinn, Richard, Kranzler, Henry R., Covault, Jonathan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135039/
https://ncbi.nlm.nih.gov/pubmed/24838369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-014-3614-2
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