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Implications of the colonic deposition of free hemoglobin-alpha chain: a previously unknown tissue by-product in inflammatory bowel disease

PURPOSE: We analyzed inflamed mucosal/submucosal layers of ulcerative colitis (UC=63) and Crohn’s colitis (CC=50) and unexpectedly we unveiled a pool of free-hemoglobin-alpha (Hb-α) chain. Patients with colitides have increased ROS, DNA-oxidation products, free-iron in mucosa, in pre-neoplastic, and...

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Detalhes bibliográficos
Main Authors: Myers, Jeremy N., Schäffer, Michael W., Korolkova, Olga Y., Williams, Amanda D., Gangula, Pandu R., M’Koma, Amosy E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134710/
https://ncbi.nlm.nih.gov/pubmed/25078150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MIB.0000000000000144
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