An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin.

Lignende værker

• Comparison of tyrosine kinase domain properties for the neurotrophin receptors TrkA and TrkB
  af: Artim, Stephen C., et al.
  Udgivet: (2020)
• NGF/BDNF chimeric proteins: analysis of neurotrophin specificity by homolog-scanning mutagenesis
  af: Suter, U, et al.
  Udgivet: (1992)
• The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin.
  af: Urfer, R, et al.
  Udgivet: (1994)
• Chimeric molecules with multiple neurotrophic activities reveal structural elements determining the specificities of NGF and BDNF.
  af: Ibáñez, C F, et al.
  Udgivet: (1991)
• Pan-neurotrophin 1: a genetically engineered neurotrophic factor displaying multiple specificities in peripheral neurons in vitro and in vivo.
  af: Ilag, L L, et al.
  Udgivet: (1995)