Altered sugar donor specificity and catalytic activity of pteridine glycosyltransferases by domain swapping or site-directed mutagenesis

CY-007 and CY-049 pteridine glycosyltransferases (PGTs) that differ in sugar donor specificity to catalyze either glucose or xylose transfer to tetrahydrobiopterin were studied here to uncover the structural determinants necessary for the specificity. The importance of the C-terminal domain and its...

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Main Authors: Kim, Hye-Lim, Kim, Ae Hyun, Park, Mi Bi, Lee, Soo-Woong, Park, Young Shik
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society for Biochemistry and Molecular Biology 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133829/
https://ncbi.nlm.nih.gov/pubmed/23351382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2013.46.1.147
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