Pig-to-baboon liver xenoperfusion utilizing GalTKO.hCD46 pigs and glycoprotein Ib blockade

BACKGROUND: Although transplantation of genetically modified porcine livers into baboons has yielded recipient survival for up to 7 days, survival is limited by profound thrombocytopenia, which becomes manifest almost immediately after revascularization, and by subsequent coagulopathy. Porcine von W...

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Hlavní autoři: LaMattina, John C., Burdorf, Lars, Zhang, Tianshu, Rybak, Elana, Cheng, Xiangfei, Munivenkatappa, Raghava, Salles, Isabelle I., Broos, Katleen, Sievert, Evelyn, McCormick, Brian, Decarlo, Marc, Ayares, David, Deckmyn, Hans, Azimzadeh, Agnes M., Pierson, Richard N., Barth, Rolf N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133776/
https://ncbi.nlm.nih.gov/pubmed/24628649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/xen.12093
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