Cell-free synthesis and assembly of prolyl 4-hydroxylase: the role of the beta-subunit (PDI) in preventing misfolding and aggregation of the alpha-subunit.

Prolyl 4-hydroxylase (P4-H) catalyses a vital post-translational modification in the biosynthesis of collagen. The enzyme consists of two distinct polypeptides forming an alpha 2 beta 2 tetramer (alpha = 64 kDa, beta = 60 kDa), the beta-subunit being identical to the multifunctional enzyme protein d...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	John, D C, Grant, M E, Bulleid, N J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413372/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8385607/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05803.x
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