In vivo Magnetic Resonance Imaging of Tumor Protease Activity

Increased expression of cathepsins has diagnostic as well as prognostic value in several types of cancer. Here, we demonstrate a novel magnetic resonance imaging (MRI) method, which uses poly-L-glutamate (PLG) as an MRI probe to map cathepsin expression in vivo, in a rat brain tumor model. This noni...

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Detalhes bibliográficos
Main Authors: Haris, Mohammad, Singh, Anup, Mohammed, Imran, Ittyerah, Ranjit, Nath, Kavindra, Nanga, Ravi Prakash Reddy, Debrosse, Catherine, Kogan, Feliks, Cai, Kejia, Poptani, Harish, Reddy, Damodar, Hariharan, Hari, Reddy, Ravinder
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133714/
https://ncbi.nlm.nih.gov/pubmed/25124082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06081
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