The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.

Mutant p53 alleles that have a recessive phenotype in human tumors can, in cooperation with an activated H-ras gene, transform rat embryo fibroblasts (REFs). Mutant p53 proteins differ from wild type, and from each other in conformation, localization and transforming potential. Missense mutations in...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Slingerland, J M, Jenkins, J R, Benchimol, S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC413304/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8458321/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1993.tb05744.x
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