Differential knockdown of TGF-β ligands in a three-dimensional co-culture tumor- stromal interaction model of lung cancer

BACKGROUND: Transforming growth factor (TGF)-β plays a pivotal role in cancer progression through regulating cancer cell proliferation, invasion, and remodeling of the tumor microenvironment. Cancer-associated fibroblasts (CAFs) are the predominant type of stromal cell, in which TGF-β signaling is a...

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Main Authors: Horie, Masafumi, Saito, Akira, Noguchi, Satoshi, Yamaguchi, Yoko, Ohshima, Mitsuhiro, Morishita, Yasuyuki, Suzuki, Hiroshi I, Kohyama, Tadashi, Nagase, Takahide
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132906/
https://ncbi.nlm.nih.gov/pubmed/25107280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-580
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