Metformin Suppresses Lipopolysaccharide (LPS)-induced Inflammatory Response in Murine Macrophages via Activating Transcription Factor-3 (ATF-3) Induction

Metformin, a well known antidiabetic agent that improves peripheral insulin sensitivity, also elicits anti-inflammatory actions, but its mechanism is unclear. Here, we investigated the mechanism responsible for the anti-inflammatory effect of metformin action in lipopolysaccharide (LPS)-stimulated m...

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Detalhes bibliográficos
Main Authors: Kim, Juyoung, Kwak, Hyun Jeong, Cha, Ji-Young, Jeong, Yun-Seung, Rhee, Sang Dahl, Kim, Kwang Rok, Cheon, Hyae Gyeong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132821/
https://ncbi.nlm.nih.gov/pubmed/24973221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.577908
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