A Coding IRAK2 Protein Variant Compromises Toll-like receptor (TLR) Signaling and Is Associated with Colorectal Cancer Survival

Within innate immune signaling pathways, interleukin-1 receptor-associated kinases (IRAKs) fulfill key roles downstream of multiple Toll-like receptors and the interleukin-1 receptor. Although human IRAK4 deficiency was shown to lead to severe immunodeficiency in response to pyogenic bacterial infec...

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Main Authors: Wang, Hui, Flannery, Sinead M., Dickhöfer, Sabine, Huhn, Stefanie, George, Julie, Kubarenko, Andriy V., Lascorz, Jesus, Bevier, Melanie, Willemsen, Joschka, Pichulik, Tica, Schafmayer, Clemens, Binder, Marco, Manoury, Bénédicte, Paludan, Søren R., Alarcon-Riquelme, Marta, Bowie, Andrew G., Försti, Asta, Weber, Alexander N. R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132810/
https://ncbi.nlm.nih.gov/pubmed/24973222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.492934
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