Cystathionine β-Synthase (CBS) Domains Confer Multiple Forms of Mg(2+)-dependent Cooperativity to Family II Pyrophosphatases

Regulated family II pyrophosphatases (CBS-PPases) contain a nucleotide-binding insert comprising a pair of cystathionine β-synthase (CBS) domains, termed a Bateman module. By binding with high affinity to the CBS domains, AMP and ADP usually inhibit the enzyme, whereas ATP activates it. Here, we dem...

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Detalhes bibliográficos
Main Authors: Salminen, Anu, Anashkin, Viktor A., Lahti, Matti, Tuominen, Heidi K., Lahti, Reijo, Baykov, Alexander A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132789/
https://ncbi.nlm.nih.gov/pubmed/24986864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.589473
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