5′ isomiR variation is of functional and evolutionary importance

We have sequenced miRNA libraries from human embryonic, neural and foetal mesenchymal stem cells. We report that the majority of miRNA genes encode mature isomers that vary in size by one or more bases at the 3′ and/or 5′ end of the miRNA. Northern blotting for individual miRNAs showed that the prop...

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Detalhes bibliográficos
Main Authors: Tan, Geok Chin, Chan, Elcie, Molnar, Attila, Sarkar, Rupa, Alexieva, Diana, Isa, Ihsan Mad, Robinson, Sophie, Zhang, Shuchen, Ellis, Peter, Langford, Cordelia F., Guillot, Pascale V., Chandrashekran, Anil, Fisk, Nick M., Castellano, Leandro, Meister, Gunter, Winston, Robert M., Cui, Wei, Baulcombe, David, Dibb, Nick J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132760/
https://ncbi.nlm.nih.gov/pubmed/25056318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku656
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