Road rules for traffic on DNA—systematic analysis of transcriptional roadblocking in vivo

Genomic DNA is bound by many proteins that could potentially impede elongation of RNA polymerase (RNAP), but the factors determining the magnitude of transcriptional roadblocking in vivo are poorly understood. Through systematic experiments and modeling, we analyse how roadblocking by the lac repres...

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Bibliografiske detaljer
Main Authors: Hao, Nan, Krishna, Sandeep, Ahlgren-Berg, Alexandra, Cutts, Erin E., Shearwin, Keith E., Dodd, Ian B.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Computational Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132739/
https://ncbi.nlm.nih.gov/pubmed/25034688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku627
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