Validation of Six Genetic Determinants of Susceptibility to Estrogen-Induced Mammary Cancer in the Rat and Assessment of Their Relevance to Breast Cancer Risk in Humans

When treated with 17β-estradiol, female ACI rats (Rattus norvegicus) rapidly develop mammary cancers that share multiple phenotypes with luminal breast cancers. Seven distinct quantitative trait loci that harbor genetic determinants of susceptibility to 17β-estradiol−induced mammary cancer have been...

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Bibliographic Details
Main Authors: Colletti, John A., Leland-Wavrin, Kristin M., Kurz, Scott G., Hickman, Maureen Peters, Seiler, Nicole L., Samanas, Nyssa Becker, Eckert, Quincy A., Dennison, Kirsten L., Ding, Lina, Schaffer, Beverly S., Shull, James D.
Format: Artigo
Language:Inglês
Published: Genetics Society of America 2014
Subjects:
Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132170/
https://ncbi.nlm.nih.gov/pubmed/24875630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.114.011163
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