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Generation of Ugt1-Deficient Murine Liver Cell Lines Using TALEN Technology
The Crigler-Najjar Syndrome Type I (CNSI) is a rare genetic disorder caused by mutations in the Ugt1a1 gene. It is characterized by unconjugated hyperbilirubinemia that may result in severe neurologic damage and death if untreated. To date, liver transplantation is the only curative treatment. With...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Public Library of Science
2014
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4132024/ https://ncbi.nlm.nih.gov/pubmed/25118822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104816 |
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