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One-step synthesis of Lycopodium alkaloid (-)-huperzine W via Suzuki-Miyaura coupling

The first total synthesis of (−)-huperzine W (1) has been achieved. Key element of the synthesis is a highly convergent assemblage for the two rings system of target molecule utilizing an efficient Suzuki-Miyaura coupling reaction between chiral iodide 2 and 2-allylpyrrolidinone 4. Evaluation of the...

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Autori principali: Xu, Tao, Jiang, Shi-Zhi, Luo, Huai-Rong, Yang, Yu-Rong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131606/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13659-012-0084-2
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