Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-cell chronic lymphocytic leukemia

Evading apoptosis is a hallmark of B-cell chronic lymphocytic leukemia (CLL) cells and an obstacle to current chemotherapeutic approaches. Inhibiting histone deacetylase (HDAC) has emerged as a promising strategy to induce cell death in malignant cells. We have previously reported that the HDAC inhi...

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Détails bibliographiques
Auteurs principaux: El-Khoury, V, Pierson, S, Szwarcbart, E, Brons, N H C, Roland, O, Cherrier-De Wilde, S, Plawny, L, Van Dyck, E, Berchem, G
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2014
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131250/
https://ncbi.nlm.nih.gov/pubmed/24418989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.19
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