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The Domain Interface of the Human Glutamate Transporter EAAT1 Mediates Chloride Permeation

The concentration of glutamate within the glutamatergic synapse is tightly regulated by the excitatory amino-acid transporters (EAATs). In addition to their primary role of clearing extracellular glutamate, the EAATs also possess a thermodynamically uncoupled Cl(−) conductance. Several crystal struc...

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Bibliografiske detaljer
Main Authors: Cater, Rosemary J., Vandenberg, Robert J., Ryan, Renae M.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4129490/
https://ncbi.nlm.nih.gov/pubmed/25099801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.05.046
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