Comparative Molecular Dynamics Simulation of Hepatitis C Virus NS3/4A Protease (Genotypes 1b, 3a and 4a) Predicts Conformational Instability of the Catalytic Triad in Drug Resistant Strains

The protease domain of the Hepatitis C Virus (HCV) nonstructural protein 3 (NS3) has been targeted for inhibition by several direct-acting antiviral drugs. This approach has had marked success to treat infections caused by HCV genotype 1 predominant in the USA, Europe, and Japan. However, genotypes...

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Bibliographische Detailangaben
Hauptverfasser: Kramer, Mitchell, Halleran, Daniel, Rahman, Moazur, Iqbal, Mazhar, Anwar, Muhammad Ikram, Sabet, Salwa, Ackad, Edward, Yousef, Mohammad
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128671/
https://ncbi.nlm.nih.gov/pubmed/25111232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104425
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