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Fluorogenic Small Molecules Requiring Reaction with a Specific Protein to Create a Fluorescent Conjugate for Biological Imaging–What we Know and What we Need to Learn

We seek fluorogenic small molecules that generate a fluorescent conjugate signal if and only if they react with a given protein-of-interest (i.e., small molecules for which non-covalent binding to the protein-of-interest is insufficient to generate fluorescence). Consequently, it is the new chemical...

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Detalhes bibliográficos
Main Authors: Baranczak, Aleksandra, Connelly, Stephen P., Liu, Yu, Choi, Sungwook, Grimster, Neil P., Powers, Evan T., Wilson, Ian A., Kelly, Jeffery W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128284/
https://ncbi.nlm.nih.gov/pubmed/24105107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.22407
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