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Agomelatine: mechanism of action and pharmacological profile in relation to antidepressant properties
Agomelatine behaves both as a potent agonist at melatonin MT(1) and MT(2) receptors and as a neutral antagonist at 5-HT(2C) receptors. Accumulating evidence in a broad range of experimental procedures supports the notion that the psychotropic effects of agomelatine are due to the synergy between its...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4128060/ https://ncbi.nlm.nih.gov/pubmed/24724693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12720 |
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