Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists

Despite high sequence similarity between NOP (nociceptin/orphanin FQ opioid peptide) and opioid receptors, marked differences in endogenous ligand selectivity, signal transduction, phosphorylation, desensitization, internalization and trafficking have been identified; underscoring the evolutionary d...

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Bibliografiske detaljer
Main Authors: Schröder, W, Lambert, D G, Ko, M C, Koch, T
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2014
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128043/
https://ncbi.nlm.nih.gov/pubmed/24762001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12744
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