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Adaptor bypass mutations of Bacillus subtilis spx suggest a mechanism for YjbH-enhanced proteolysis of the regulator Spx by ClpXP

The global regulator, Spx, is under proteolytic control exerted by the adaptor YjbH and ATP-dependent protease ClpXP in Bacillus subtilis. While YjbH is observed to bind the Spx C-terminus, YjbH shows little affinity for ClpXP, indicating adaptor activity that does not operate by tethering. Chimeric...

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Hlavní autoři: Chan, Chio Mui, Hahn, Erik, Zuber, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128009/
https://ncbi.nlm.nih.gov/pubmed/24942655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12671
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