Antagonizing Arachidonic Acid-Derived Eicosanoids Reduces Inflammatory Th17 and Th1 Cell-Mediated Inflammation and Colitis Severity

During colitis, activation of two inflammatory T cell subsets, Th17 and Th1 cells, promotes ongoing intestinal inflammatory responses. n-6 polyunsaturated fatty acid- (PUFA-) derived eicosanoids, such as prostaglandin E(2) (PGE(2)), promote Th17 cell-mediated inflammation, while n-3 PUFA antagonize...

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Hlavní autoři: Monk, Jennifer M., Turk, Harmony F., Fan, Yang-Yi, Callaway, Evelyn, Weeks, Brad, Yang, Peiying, McMurray, David N., Chapkin, Robert S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4127240/
https://ncbi.nlm.nih.gov/pubmed/25136149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/917149
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