Hinokitiol Induces DNA Damage and Autophagy followed by Cell Cycle Arrest and Senescence in Gefitinib-Resistant Lung Adenocarcinoma Cells

Despite good initial responses, drug resistance and disease recurrence remain major issues for lung adenocarcinoma patients with epidermal growth factor receptor (EGFR) mutations taking EGFR-tyrosine kinase inhibitors (TKI). To discover new strategies to overcome this issue, we investigated 40 essen...

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Hlavní autoři: Li, Lan-Hui, Wu, Ping, Lee, Jen-Yi, Li, Pei-Rong, Hsieh, Wan-Yu, Ho, Chao-Chi, Ho, Chen-Lung, Chen, Wan-Jiun, Wang, Chien-Chun, Yen, Muh-Yong, Yang, Shun-Min, Chen, Huei-Wen
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126702/
https://ncbi.nlm.nih.gov/pubmed/25105411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104203
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