Merlin/NF2-loss Driven Tumorigenesis Linked to CRL4(DCAF1)-Mediated Inhibition of the Hippo Pathway Components Lats1 and 2 in the Nucleus

It is currently unclear if Merlin/NF2 suppresses tumorigenesis by activating upstream components of the Hippo pathway at the plasma membrane or by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus. We found that de-repressed CRL4(DCAF1) promotes YAP and TEAD-dependent transcription by ub...

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Detalhes bibliográficos
Main Authors: Li, Wei, Cooper, Jonathan, Zhou, Lu, Yang, Chenyi, Erdjument-Bromage, Hediye, Zagzag, David, Snuderl, Matija, Ladanyi, Marc, Hanemann, C. Oliver, Zhou, Pengbo, Karajannis, Matthias A., Giancotti, Filippo G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126592/
https://ncbi.nlm.nih.gov/pubmed/25026211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.05.001
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