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Manganese inhibits mitochondrial aconitase: a mechanism of manganese neurotoxicity()

The symptoms of Mn-induced neurotoxicity resemble those of Parkinson’s diseases. Since iron (Fe) appears to play a pivotal role in pathophysiology of Parkinson’s disease, we set out to test the hypothesis that alterations in Fe-requiring enzymes such as aconitase contribute to Mn-induced neurotoxici...

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Autores principales: Zheng, Wei, Ren, Sean, Graziano, Joseph H.
Formato: Artigo
Lenguaje:Inglês
Publicado: 1998
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126159/
https://ncbi.nlm.nih.gov/pubmed/9675333
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