Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice

AIM: Aliskiren (ALK) is a renin inhibitor that has been used in the treatment of hypertension. The aim of this study was to determine whether ALK could ameliorate pressure overload-induced heart hypertrophy and fibrosis, and to elucidate the mechanisms of action. METHODS: Transverse aortic constrict...

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Autors principals: Weng, Li-qing, Zhang, Wen-bin, Ye, Yong, Yin, Pei-pei, Yuan, Jie, Wang, Xing-xu, Kang, Le, Jiang, Sha-sha, You, Jie-yun, Wu, Jian, Gong, Hui, Ge, Jun-bo, Zou, Yun-zeng
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125714/
https://ncbi.nlm.nih.gov/pubmed/24998254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.45
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