Hemodynamic and antifibrotic effects of a selective liver nitric oxide donor V-PYRRO/NO in bile duct ligated rats

AIM: To assess whether a liver specific nitric oxide (NO) donor (V-PYRRO/NO) would prevent the development of portal hypertension and liver fibrosis in rats with bile duct ligation (BDL). METHODS: Treatment (placebo or V-PYRRO/NO 0.53 μmol/kg per hour) was administered i.v. to rats 2 d before BDL (D...

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Autores principales: Moal, Frédéric, Veal, Nary, Vuillemin, Eric, Barrière, Eric, Wang, Jianhua, Fizanne, Lionel, Oberti, Frédéric, Douay, Olivier, Gallois, Yves, Bonnefont-Rousselot, Dominique, Rousselet, Marie Christine, Calès, Paul
Formato: Artigo
Lenguaje:Inglês
Publicado: Baishideng Publishing Group Co., Limited 2006
Materias:
Basic Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125669/
https://ncbi.nlm.nih.gov/pubmed/17075977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v12.i41.6639
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