Inactivating Mutation in the Prostaglandin Transporter Gene, SLCO2A1, Associated With Familial Digital Clubbing, Colon Neoplasia, and NSAID Resistance

HPGD and SLCO2A1 genes encode components of the prostaglandin catabolic pathway, HPGD encoding the degradative enzyme 15-PGDH, and SLCO2A1 encoding the prostaglandin transporter PGT that brings substrate to 15-PGDH. HPGD null mice show increased PGE(2), marked susceptibility to developing colon tumo...

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Auteurs principaux: Guda, Kishore, Fink, Stephen P., Milne, Ginger L., Molyneaux, Neil, Ravi, Lakshmeswari, Lewis, Susan M., Dannenberg, Andrew J., Montgomery, Courtney G., Zhang, Shulin, Willis, Joseph, Wiesner, Georgia L., Markowitz, Sanford D.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125515/
https://ncbi.nlm.nih.gov/pubmed/24838973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-14-0108
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