APOε 4 is associated with enhanced in vivo innate immune responses in humans

BACKGROUND: The genetic determinants of the human innate immune response are poorly understood. Apolipoprotein (apo)E, a lipid-trafficking protein that impacts inflammation, has well-described ‘wild type’ (ε3) and disease-associated (ε2, ε4) alleles, but its connection to human innate immunity is un...

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Detalhes bibliográficos
Main Authors: Gale, Stephen C., Gao, Li, Mikacenic, Carmen, Coyle, Susette M., Rafaels, Nicholas, Murray, Tanda, Madenspacher, Jennifer H., Draper, David W., Ge, William, Aloor, Jim J., Azzam, Kathleen M., Lai, Lihua, Blackshear, Perry J., Calvano, Steven E., Barnes, Kathleen C., Lowry, Stephen F., Corbett, Siobhan, Wurfel, Mark M., Fessler, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125509/
https://ncbi.nlm.nih.gov/pubmed/24655576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.01.032
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