Molecular Basis for Unidirectional Scaffold Switching of Human Plk4 in Centriole Biogenesis

Polo-like kinase 4 (Plk4) is a key regulator of centriole duplication, an event critical for the maintenance of genomic integrity. Here we showed that Plk4 relocalizes from the inner Cep192 ring to the outer Cep152 ring as newly recruited Cep152 assembles around the Cep192-encircled daughter centrio...

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Hoofdauteurs: Park, Suk-Youl, Park, Jung-Eun, Kim, Tae-Sung, Kim, Ju Hee, Kwak, Mi-Jeong, Ku, Bonsu, Tian, Lan, Murugan, Ravichandran N., Ahn, Mija, Komiya, Shinobu, Hojo, Hironobu, Kim, Nam-Hyung, Kim, Bo Yeon, Bang, Jeong K., Erikson, Raymond L., Lee, Ki Won, Kim, Seung Jun, Oh, Byung-Ha, Yang, Wei, Lee, Kyung S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125498/
https://ncbi.nlm.nih.gov/pubmed/24997597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2846
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