Mouse xenograft modeling of human adult acute lymphoblastic leukemia provides mechanistic insights into adult LIC biology

The distinct nature of acute lymphoblastic leukemia (ALL) in adults, evidenced by inferior treatment outcome and different genetic landscape, mandates specific studies of disease-initiating mechanisms. In this study, we used NOD/LtSz-scid IL2Rγ null(c) (NSG) mouse xenotransplantation approaches to e...

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Autors principals: Patel, Bella, Dey, Aditi, Castleton, Anna Z., Schwab, Claire, Samuel, Edward, Sivakumaran, Janani, Beaton, Brendan, Zareian, Nahid, Zhang, Christie Yu, Rai, Lena, Enver, Tariq, Moorman, Anthony V., Fielding, Adele K.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2014
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125358/
https://ncbi.nlm.nih.gov/pubmed/24825861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-549352
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