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Mouse xenograft modeling of human adult acute lymphoblastic leukemia provides mechanistic insights into adult LIC biology

The distinct nature of acute lymphoblastic leukemia (ALL) in adults, evidenced by inferior treatment outcome and different genetic landscape, mandates specific studies of disease-initiating mechanisms. In this study, we used NOD/LtSz-scid IL2Rγ null(c) (NSG) mouse xenotransplantation approaches to e...

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Detalhes bibliográficos
Main Authors: Patel, Bella, Dey, Aditi, Castleton, Anna Z., Schwab, Claire, Samuel, Edward, Sivakumaran, Janani, Beaton, Brendan, Zareian, Nahid, Zhang, Christie Yu, Rai, Lena, Enver, Tariq, Moorman, Anthony V., Fielding, Adele K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125358/
https://ncbi.nlm.nih.gov/pubmed/24825861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-549352
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