Deoxycytidine Kinase Augments ATM-Mediated DNA Repair and Contributes to Radiation Resistance

Efficient and adequate generation of deoxyribonucleotides is critical to successful DNA repair. We show that ataxia telangiectasia mutated (ATM) integrates the DNA damage response with DNA metabolism by regulating the salvage of deoxyribonucleosides. Specifically, ATM phosphorylates and activates de...

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Main Authors: Bunimovich, Yuri L., Nair-Gill, Evan, Riedinger, Mireille, McCracken, Melissa N., Cheng, Donghui, McLaughlin, Jami, Radu, Caius G., Witte, Owen N.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125169/
https://ncbi.nlm.nih.gov/pubmed/25101980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104125
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