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Inactivation of Factor VIIa by Antithrombin In Vitro, Ex Vivo and In Vivo: Role of Tissue Factor and Endothelial Cell Protein C Receptor

Recent studies have suggested that antithrombin (AT) could act as a significant physiologic regulator of FVIIa. However, in vitro studies showed that AT could inhibit FVIIa effectively only when it was bound to tissue factor (TF). Circulating blood is known to contain only traces of TF, at best. FVI...

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Main Authors: Vatsyayan, Rit, Kothari, Hema, Mackman, Nigel, Pendurthi, Usha R., Rao, L. Vijaya Mohan
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125150/
https://ncbi.nlm.nih.gov/pubmed/25102166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103505
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