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Combining low-dose cyclophosphamide with GM-CSF–secreting prostate cancer immunotherapy enhances antitumor immune effects

Prostate GVAX(®) is an allogeneic cell-based prostate cancer vaccine engineered to secrete GM-CSF. The release of GM-CSF by this immunotherapy serves to recruit dendritic cells, which then present tumor antigens to T cells, thus initiating antitumor immune responses. However, preclinical data show t...

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Hlavní autoři: Antonarakis, Emmanuel S, Carducci, Michael A
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4124637/
https://ncbi.nlm.nih.gov/pubmed/20047504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/13543780903530678
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