Asparagine synthetase is a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines

We recently used RNAi to demonstrate that a negative correlation of L-asparaginase (L-ASP) chemotherapeutic activity with asparagine synthetase (ASNS) expression in the ovarian subset of the NCI-60 cell line panel is causal. To determine whether that relationship would be sustained in a larger, more...

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Hauptverfasser: Lorenzi, Philip L., Llamas, Jenny, Gunsior, Michele, Ozbun, Laurent, Reinhold, William C., Varma, Sudhir, Ji, Helen, Kim, Hijoo, Hutchinson, Amy A., Kohn, Elise C., Goldsmith, Paul K., Birrer, Michael J., Weinstein, John N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123961/
https://ncbi.nlm.nih.gov/pubmed/18852115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0589
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