Asparagine synthetase is a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines

We recently used RNAi to demonstrate that a negative correlation of L-asparaginase (L-ASP) chemotherapeutic activity with asparagine synthetase (ASNS) expression in the ovarian subset of the NCI-60 cell line panel is causal. To determine whether that relationship would be sustained in a larger, more...

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Detalhes bibliográficos
Main Authors: Lorenzi, Philip L., Llamas, Jenny, Gunsior, Michele, Ozbun, Laurent, Reinhold, William C., Varma, Sudhir, Ji, Helen, Kim, Hijoo, Hutchinson, Amy A., Kohn, Elise C., Goldsmith, Paul K., Birrer, Michael J., Weinstein, John N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123961/
https://ncbi.nlm.nih.gov/pubmed/18852115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0589
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