TLR9 Ligands Induce S100A8 in Macrophages via a STAT3-Dependent Pathway which Requires IL-10 and PGE(2)

S100A8 and S100A9 are highly-expressed calcium-binding proteins in neutrophils and monocytes, and in subsets of macrophages in inflammatory lesions. Unmethylated CpG motifs found in bacterial and viral DNA are potent activators of innate immunity via Toll-like receptor 9 (TLR9). S100A8, but not S100...

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Bibliographic Details
Main Authors: Hsu, Kenneth, Chung, Yuen Ming, Endoh, Yasumi, Geczy, Carolyn L.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123874/
https://ncbi.nlm.nih.gov/pubmed/25098409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103629
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