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Role of Hydrophobic Mutations on the Binding Affinity and Stability of Blood Coagulation Factor VIIIa: A Computational Molecular Dynamics and Free-Energy Analysis
Factor VIIIa is a non-covalently bound hetero-trimer among A1, A2 and A3-C1-C2 domains and an essential co-factor for factor IXa enzyme during proteolytic activation of factor X zymogen. The relatively weak interactions between A2 and the interface A1/A3 domains dampen the functional stability of FV...
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| Natura: | Artigo |
| Lingua: | Inglês |
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2014
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4123457/ https://ncbi.nlm.nih.gov/pubmed/24952158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.06.043 |
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