Potential Use of Sox9 Gene Therapy for Intervertebral Degenerative Disc Disease

STUDY DESIGN: A new recombinant adenoviral vector expressing Sox9, a chondrocyte-specific transcription factor, was tested in a chondroblastic cell line and primary human intervertebral disc cells in vitro. Direct infection of intervertebral disc cells then was assessed in a rabbit model. OBJECTIVES...

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Main Authors: Paul, Ronjon, Haydon, Rex C., Cheng, Hongwei, Ishikawa, Akira, Nenadovich, Nikola, Jiang, Wei, Zhou, Lan, Breyer, Benjamin, Feng, Tao, Gupta, Purnendu, He, Tong-Chuan, Phillips, Frank M.
Format: Artigo
Sprog:Inglês
Udgivet: 2003
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123440/
https://ncbi.nlm.nih.gov/pubmed/12698117
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