Immortalised breast epithelia survive prolonged DNA replication stress and return to cycle from a senescent-like state

Mammalian cells have mechanisms to counteract the effects of metabolic and exogenous stresses, many of that would be mutagenic if ignored. Damage arising during DNA replication is a major source of mutagenesis. The extent of damage dictates whether cells undergo transient cell cycle arrest and damag...

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Detalhes bibliográficos
Main Authors: Maya-Mendoza, A, Merchut-Maya, J M, Bartkova, J, Bartek, J, Streuli, C H, Jackson, D A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123104/
https://ncbi.nlm.nih.gov/pubmed/25058425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.315
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