Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency

Loss of ataxia telangiectasia mutated (ATM) kinase, a key factor of the DNA damage response (DDR) pathway, causes the cancer predisposing and neurodegenerative syndrome ataxia-telangiectasia (A-T). To investigate the mechanisms of neurodegeneration, we have reprogrammed fibroblasts from ATM-null A-T...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Carlessi, L, Poli, E Fusar, Bechi, G, Mantegazza, M, Pascucci, B, Narciso, L, Dogliotti, E, Sala, C, Verpelli, C, Lecis, D, Delia, D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123100/
https://ncbi.nlm.nih.gov/pubmed/25032865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.310
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados