Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17

Transforming growth factor-beta (TGF-β) plays a dual role in hepatocytes, inducing both pro- and anti-apoptotic responses, whose balance decides cell fate. Survival signals are mediated by the epidermal growth factor receptor (EGFR) pathway, which is activated by TGF-β in these cells. Caveolin-1 (Ca...

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Autori principali: Moreno-Càceres, J, Caja, L, Mainez, J, Mayoral, R, Martín-Sanz, P, Moreno-Vicente, R, del Pozo, M Á, Dooley, S, Egea, G, Fabregat, I
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123087/
https://ncbi.nlm.nih.gov/pubmed/25032849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.294
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