CHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2

Apoptosis-stimulating protein of p53-2 (ASPP2) induces apoptosis by promoting the expression of pro-apoptotic genes via binding to p53 or p73; however, the exact mechanisms by which ASPP2 induces apoptotic death in hepatoma cells are still unclear. Here, we show that the transient overexpression of...

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Detalhes bibliográficos
Main Authors: Liu, K, Shi, Y, Guo, X, Wang, S, Ouyang, Y, Hao, M, Liu, D, Qiao, L, Li, N, Zheng, J, Chen, D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123070/
https://ncbi.nlm.nih.gov/pubmed/25032846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.276
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