Target Engagement Analysis and Link to Pharmacodynamic Endpoint for a Novel Class of CNS-penetrant and Efficacious p38α MAPK Inhibitors

Lignende værker

• The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS
  af: Bachstetter, Adam D., et al.
  Udgivet: (2010)
• Inhibition of Neuronal p38α, but not p38β MAPK, Provides Neuroprotection Against Three Different Neurotoxic Insults
  af: Xing, Bin, et al.
  Udgivet: (2014)
• Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα
  af: Xing, Bin, et al.
  Udgivet: (2011)
• Deficiency in p38β MAPK Fails to Inhibit Cytokine Production or Protect Neurons against Inflammatory Insult in In Vitro and In Vivo Mouse Models
  af: Xing, Bin, et al.
  Udgivet: (2013)
• The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism
  af: Bachstetter, Adam D, et al.
  Udgivet: (2014)