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Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency

Although aberrant mTORC1 signaling has been well established in models of obesity, little is known about its repressor, REDD1. Therefore, the initial goal of this study was to determine the role of REDD1 on mTORC1 in obese skeletal muscle. REDD1 expression (protein and message) and mTORC1 signaling...

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Main Authors: Williamson, David L., Li, Zhuyun, Tuder, Rubin M., Feinstein, Elena, Kimball, Scot R., Dungan, Cory M.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122690/
https://ncbi.nlm.nih.gov/pubmed/24876363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.01350.2013
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